Immunosupressive activity of opportunist pathogens of the infectious-inflammatory process in the urinary tract of men with calculous pyelonephritis

Objective - identification of pathogens the infectious-inflammatory process urinary tract in men with calculous pyelonephritis, antilysozyme, anticomplementary, anti-immunoglobulin activity and inhibitory effect on phagocytic peripheral blood neutrophils.Material methods. 34 strains opportunistic taxa were isolated identified by bacteriological method from 30 sick aged 31 to 65 years (mean age 48.8 ± 4.27 years). These bacteria have anti-complementary activity, as well suppressive supernatants cultures pyelonephritis neutrophils patients. The determination was carried out using principle, which includes testing protective action their metabolic products against growth an indicator strain presence a bactericidal substance (complement serum). antilysozyme investigated photometric method. Anti-immunoglobulin studied described work I.S. Gaidash et al. Results. majority 27 (79.41%) Enterobacteriaceae (84%) facultative anaerobic aerobic gram-positive cocci (E. faecalis, S.saprophyticus) (66.67%) exhibit varying degrees. highest found K. pneumoniae, 8.14% lower – E. coli. Most (64.71%) (68%) (55.56%) activity. All immunoglobulins main classes: Ig M, G, A. K.pneumoniae inhibits all major classes, concentration M decreases under influence this taxon 22.36%, G 26.88% A 19.61%.Conclusions. Opportunistic coli, P. mirabilis, cloaceae, S. marcescens, saprophyticus) different levels activity; reduce function (by 21.60%), 21.49%) 14.30%), inhibit neutrophilsby 15.74%, capturing ability- 22.59%.